Richard A Yost

Richard A Yost,

Professor

Department: LS-CHEMISTRY-GENERAL
Business Phone: (352) 392-0557
Business Email: ryost@ufl.edu

About Richard A Yost

Dr. Yost is the University Professor and Head of Analytical Chemistry at the University of Florida. He is also director of the Southeast Center for Integrated Metabolomics (SECIM) and of NIH’s Metabolomics Consortium Coordinating Center (M3C). He is recognized internationally as a leader in the field of analytical chemistry, particularly tandem mass spectrometry (MS/MS). His research has been recognized with the ASMS Award for Distinguished Contribution in Mass Spectrometry, the MSACL Award for Distinguished Contribution to Clinical Mass Spectrometry, and the Florida Academy of Sciences Medal. He has also been inducted into the National Academy of Inventors. Dr. Yost currently serves as Past President of the American Society for Mass Spectrometry (ASMS).

Related Links:

Teaching Profile

Courses Taught
2009-2010,2014-2021
CHM2051 Honors General Chemistry 2
2018
CHM6190 Analytical Chemistry Seminar
2018
CHM7980 Research for Doctoral Dissertation
2018
CHM7979 Advanced Research
2018,2021
CHM4910 Undergraduate Research
2018
GMS7980 Research for Doctoral Dissertation
2006,2008-2013,2013-2015
CHM6159 Mass Spectrometric Methods
2006
CHM1083 Consumer Chemistry

Research Profile

Research in my group is focused on analytical mass spectrometry, particularly tandem mass spectrometry (MS/MS), making our group one of the most widely cited of any research program in analytical chemistry. Our current research efforts focus on innovations in imaging mass spectrometry and ion mobility instrumentation and techniques, and the application of these innovations in areas such as clinical and metabolomic analysis. Our group’s research has reflected a unique balance between fundamental studies, instrumentation development, and applications in analytical chemistry. Several instruments conceived and developed by me and my group are widely used as commercial instruments (with well over $1 billion in instrument sales each year), including the triple quadrupole mass spectrometer, the ion trap tandem mass spectrometer, and the laser microprobe tandem mass spectrometer. We have also been pioneers in imaging biomolecules in intact tissue, quantitative MALDI tandem mass spectrometry, and ion mobility/mass spectrometry (IMS and FAIMS).

I have supervised the research of over 120 graduate students over the past 40 years, graduating nearly 100 PhDs and 18 MSs; my current group includes 12 PhD candidates. Research in the group has led to over 230 publications and 25 patents. I have served as PI or Co-PI on over 100 grants or contracts, totaling over $60M of funding. My research has been recognized with the highest award in my discipline, the 1993 ASMS Award for Distinguished Contribution in Mass Spectrometry, as well as the 2018 MSACL Distinguished Contribution Award in Clinical Mass Spectrometry and the 2021 Pittsburgh Analytical Chemistry Award.

I have extensive experience in leadership and governance in academics. I serve as Head of Analytical Chemistry, one of the most highly rated academic programs on the UF campus (consistently ranked in the top 10 nationwide). I have also served as Associate Dean for Research. I have served on the UF Board of Trustees and on the state of Florida Board of Governors (Regents). I have served three times on the Board of Directors of the American Society for Mass Spectrometry (ASMS), and currently serve as Past President of ASMS.

Although my faculty appointment is in the College of Liberal Arts & Sciences, I have been heavily involved in collaborative research around campus, including with the Colleges of Medicine, Agriculture and Life Sciences, Pharmacy, Veterinary Medicine, and Engineering. I direct both the NIH Metabolomics Consortium Coordinating Center (M3C) and the Southeast Center for Integrated Metabolomics (SECIM); I serve on the Executive Committee of UF’s CTSI (Clinical and Translational Sciences Institute) since it was founded, as well as on the CTSI’s Translational Technologies and Resources Advisory Committee. I am a Senior Member of the UF Health Cancer Center, a founding member of the UF Maples Center for Forensic Science, a member of the UF Emerging Pathogens Institute, served as a fellow and advisory board member of the UF Institute for Science and Health Policy, and was a Visiting Pathologist at the University of Utah in 2012.

Open Researcher and Contributor ID (ORCID)

0000-0002-1293-5669

Areas of Interest
  • Clinical Chemistry
  • Metabolomics

Publications

2023
Characterization of Bile Acid Isomers and the Implementation of High-Resolution Demultiplexing with Ion Mobility-Mass Spectrometry
Journal of the American Society for Mass Spectrometry. 34(7):1477-1490 [DOI] 10.1021/jasms.3c00143.
2023
Expanding Per- and Polyfluoroalkyl Substances Coverage in Nontargeted Analysis Using Data-Independent Analysis and IonDecon
Journal of the American Society for Mass Spectrometry. 34(11):2525-2537 [DOI] 10.1021/jasms.3c00244.
2023
Metabolomic and Lipidomic Characterization of Meningioma Grades Using LC–HRMS and Machine Learning
Journal of the American Society for Mass Spectrometry. 34(10):2187-2198 [DOI] 10.1021/jasms.3c00158.
2023
Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury.
Molecular neurobiology. 60(4):2295-2319 [DOI] 10.1007/s12035-022-03165-y. [PMID] 36635478.
2023
Segmented Flow Strategies for Integrating Liquid Chromatography–Mass Spectrometry with Nuclear Magnetic Resonance for Lipidomics
Analytical Chemistry. 95(3):1908-1915 [DOI] 10.1021/acs.analchem.2c03974. [PMID] 36630396.
2022
A rapid and robust method for amino acid quantification using a simple N-hydroxysuccinimide ester derivatization and liquid chromatography-ion mobility-mass spectrometry.
Analytical and bioanalytical chemistry. 414(18):5549-5559 [DOI] 10.1007/s00216-022-03993-w. [PMID] 35338375.
2022
Generation and Release of Neurogranin, Vimentin, and MBP Proteolytic Peptides, Following Traumatic Brain Injury.
Molecular neurobiology. 59(2):731-747 [DOI] 10.1007/s12035-021-02600-w. [PMID] 34762230.
2022
Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage.
Hepatology communications. 6(3):513-525 [DOI] 10.1002/hep4.1825. [PMID] 34811964.
2022
Per- and Polyfluoroalkyl Substances (PFAS) in Street Sweepings
Environmental Science & Technology. 56(10):6069-6077 [DOI] 10.1021/acs.est.1c03766.
2022
The triple quadrupole: Innovation, serendipity and persistence.
Journal of mass spectrometry and advances in the clinical lab. 24:90-99 [DOI] 10.1016/j.jmsacl.2022.05.001. [PMID] 35602308.
2022
Why tandem mass spectrometry for trace analysis: Concepts of tandem analytical techniques
Rapid Communications in Mass Spectrometry. 36(13) [DOI] 10.1002/rcm.9310.
2021
Characterization and standardization of multiassay platforms for four commonly studied traumatic brain injury protein biomarkers: a TBI Endpoints Development Study.
Biomarkers in medicine. 15(18):1721-1732 [DOI] 10.2217/bmm-2021-0284. [PMID] 34674546.
2021
Evaluation of extraction workflows for quantitative analysis of per- and polyfluoroalkyl substances: A case study using soil adjacent to a landfill.
The Science of the total environment. 760 [DOI] 10.1016/j.scitotenv.2020.143944. [PMID] 33341607.
2021
Mass Spectrometry-Based Cellular Metabolomics: Current Approaches, Applications, and Future Directions
Analytical Chemistry. 93(1):546-566 [DOI] 10.1021/acs.analchem.0c04363.
2021
Metabolomic and lipidomic characterization of an X-chromosome deletion disorder in neural progenitor cells by UHPLC-HRMS.
Journal of mass spectrometry and advances in the clinical lab. 20:11-24 [DOI] 10.1016/j.jmsacl.2021.05.002. [PMID] 34820667.
2021
Per- and polyfluoroalkyl substances (PFAS) in sediments collected from the Pensacola Bay System watershed.
Environmental advances. 5:1-8 [DOI] 10.1016/j.envadv.2021.100088. [PMID] 38268644.
2020
Analysis of Tryptophan Metabolites in Serum Using Wide-Isolation Strategies for UHPLC–HRMS/MS
Analytical Chemistry. 92(3):2550-2557 [DOI] 10.1021/acs.analchem.9b04210.
2020
Design and Implementation of a Dual-Probe Microsampling Apparatus for the Direct Analysis of Adherent Mammalian Cells by Ion Mobility-Mass Spectrometry
Analytical Chemistry. 92(17):12055-12061 [DOI] 10.1021/acs.analchem.0c02714.
2020
Environmental lipidomics: understanding the response of organisms and ecosystems to a changing world.
Metabolomics : Official journal of the Metabolomic Society. 16(5) [DOI] 10.1007/s11306-020-01665-3. [PMID] 32307636.
2020
Lipid Annotator: Towards Accurate Annotation in Non-Targeted Liquid Chromatography High-Resolution Tandem Mass Spectrometry (LC-HRMS/MS) Lipidomics Using A Rapid and User-Friendly Software.
Metabolites. 10(3) [DOI] 10.3390/metabo10030101. [PMID] 32178227.
2020
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.
PloS one. 15(7) [DOI] 10.1371/journal.pone.0224952. [PMID] 32692785.
2020
Separation of Structurally Similar Anabolic Steroids as Cation Adducts in FAIMS-MS
Journal of the American Society for Mass Spectrometry. 31(2):355-365 [DOI] 10.1021/jasms.9b00127.
2020
Tissue-specific analysis of lipid species in Drosophila during overnutrition by UHPLC-MS/MS and MALDI-MSI.
Journal of lipid research. 61(3):275-290 [DOI] 10.1194/jlr.RA119000198. [PMID] 31900315.
2020
Ultrahigh-Performance Liquid Chromatography–High-Resolution Mass Spectrometry Metabolomics and Lipidomics Study of Stool from Transgenic Parkinson’s Disease Mice Following Immunotherapy
Journal of Proteome Research. 19(1):424-431 [DOI] 10.1021/acs.jproteome.9b00605.
2019
Behavior of transition metal salts during the electrospray ionization process
International Journal of Mass Spectrometry. [DOI] 10.1016/j.ijms.2019.116217.
2019
Effective Liquid Chromatography–Trapped Ion Mobility Spectrometry–Mass Spectrometry Separation of Isomeric Lipid Species
Analytical Chemistry. 91(8):5021-5027 [DOI] 10.1021/acs.analchem.8b04979.
2019
Effects of Solvent Vapor Modifiers for the Separation of Opioid Isomers in Micromachined FAIMS-MS.
Journal of the American Society for Mass Spectrometry. 30(5):731-742 [DOI] 10.1007/s13361-019-02175-w. [PMID] 30877655.
2019
High resolution/accurate mass tandem MS of isotopically complex cluster ions from the artists’ pigment lead white
International Journal of Mass Spectrometry. 439:19-26 [DOI] 10.1016/j.ijms.2019.01.010.
2019
Lipidomics for wildlife disease etiology and biomarker discovery: a case study of pansteatitis outbreak in South Africa.
Metabolomics : Official journal of the Metabolomic Society. 15(3) [DOI] 10.1007/s11306-019-1490-9. [PMID] 30838461.
2019
Measuring the Integrity of Gas-Phase Conformers of Sodiated 25-Hydroxyvitamin D3 by Drift Tube, Traveling Wave, Trapped, and High-Field Asymmetric Ion Mobility
Analytical Chemistry. 91(6):4092-4099 [DOI] 10.1021/acs.analchem.8b05723.
2019
Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges
International Journal of Molecular Sciences. 20(20) [DOI] 10.3390/ijms20205213. [PMID] 31640160.
2019
Rapid Quantitation of 25-Hydroxyvitamin D2 and D3 in Human Serum Using Liquid Chromatography/Drift Tube Ion Mobility-Mass Spectrometry
Analytical Chemistry. 91(21):13555-13561 [DOI] 10.1021/acs.analchem.9b02683.
2019
Recent progress in metabolomics using ion mobility-mass spectrometry
TrAC Trends in Analytical Chemistry. 116:274-281 [DOI] 10.1016/j.trac.2019.05.001.
2019
Software tool for internal standard based normalization of lipids, and effect of data-processing strategies on resulting values.
BMC bioinformatics. 20(1) [DOI] 10.1186/s12859-019-2803-8. [PMID] 31035918.
2018
Cation-dependent conformations in 25-hydroxyvitamin D3-cation adducts measured by ion mobility-mass spectrometry and theoretical modeling
International Journal of Mass Spectrometry. 432:1-8 [DOI] 10.1016/j.ijms.2018.05.013. [PMID] 30034270.
2018
Examining heat treatment for stabilization of the lipidome.
Bioanalysis. 10(5):291-305 [DOI] 10.4155/bio-2017-0209. [PMID] 29451398.
2018
Influence of Experimental Conditions on the Ratio of 25-Hydroxyvitamin D3 Conformers for Validating a Liquid Chromatography/Ion Mobility-Mass Spectrometry Method for Routine Quantitation
Analytical Chemistry. 90(22):13549-13556 [DOI] 10.1021/acs.analchem.8b03668.
2018
Integration of paper spray ionization high-field asymmetric waveform ion mobility spectrometry for forensic applications.
Rapid communications in mass spectrometry : RCM. 32(7):552-560 [DOI] 10.1002/rcm.8068. [PMID] 29380926.
2018
l-Carnitine Inhibits Lipopolysaccharide-Induced Nitric Oxide Production of SIM-A9 Microglia Cells
ACS Chemical Neuroscience. 9(5):901-905 [DOI] 10.1021/acschemneuro.7b00468.
2018
Mass Spectrometric Methodologies for Investigating the Metabolic Signatures of Parkinson’s Disease: Current Progress and Future Perspectives
Analytical Chemistry. 90(5):2979-2986 [DOI] 10.1021/acs.analchem.7b04084.
2018
NIST lipidomics workflow questionnaire: an assessment of community-wide methodologies and perspectives.
Metabolomics : Official journal of the Metabolomic Society. 14(5) [DOI] 10.1007/s11306-018-1340-1. [PMID] 30830346.
2018
Optimization of Folch, Bligh-Dyer, and Matyash sample-to-extraction solvent ratios for human plasma-based lipidomics studies
Analytica Chimica Acta. 1037:351-357 [DOI] 10.1016/j.aca.2018.08.004. [PMID] 30292311.
2018
Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis.
American journal of physiology. Endocrinology and metabolism. 315(2):E163-E173 [DOI] 10.1152/ajpendo.00023.2018. [PMID] 29634314.
2017
A Robust Lipidomics Workflow for Mammalian Cells, Plasma, and Tissue Using Liquid-Chromatography High-Resolution Tandem Mass Spectrometry.
Methods in molecular biology (Clifton, N.J.). 1609:91-106 [DOI] 10.1007/978-1-4939-6996-8_10. [PMID] 28660577.
2017
Application of paper spray ionization for explosives analysis
Rapid Communications in Mass Spectrometry. 31(19):1565-1572 [DOI] 10.1002/rcm.7932.
2017
Common cases of improper lipid annotation using high-resolution tandem mass spectrometry data and corresponding limitations in biological interpretation.
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1862(8):766-770 [DOI] 10.1016/j.bbalip.2017.02.016. [PMID] 28263877.
2017
Corrigendum to “Common cases of improper lipid annotation using high-resolution tandem mass spectrometry data and corresponding limitations in biological interpretation” [Biochim. Biophys. Acta 1862(8) (2017) 766-770].
Biochimica et biophysica acta. Molecular and cell biology of lipids. 1862(9) [DOI] 10.1016/j.bbalip.2017.06.013. [PMID] 28648965.
2017
Expanding Lipidome Coverage Using LC-MS/MS Data-Dependent Acquisition with Automated Exclusion List Generation.
Journal of the American Society for Mass Spectrometry. 28(5):908-917 [DOI] 10.1007/s13361-017-1608-0. [PMID] 28265968.
2017
Experimental and Theoretical Investigation of Sodiated Multimers of Steroid Epimers with Ion Mobility-Mass Spectrometry.
Journal of the American Society for Mass Spectrometry. 28(2):323-331 [DOI] 10.1007/s13361-016-1525-7. [PMID] 27914014.
2017
Identification of Meliatoxins in Melia azedarach Extracts Using Mass Spectrometry for Quality Control.
Planta medica. 83(3-04):312-317 [DOI] 10.1055/s-0042-115773. [PMID] 27599262.
2017
Investigating Differences in Gas-Phase Conformations of 25-Hydroxyvitamin D3 Sodiated Epimers using Ion Mobility-Mass Spectrometry and Theoretical Modeling.
Journal of the American Society for Mass Spectrometry. 28(8):1497-1505 [DOI] 10.1007/s13361-017-1673-4. [PMID] 28417307.
2017
Ion Mobility-Mass Spectrometry Separation of Steroid Structural Isomers and Epimers
International Journal for Ion Mobility Spectrometry. 20(1-2):31-39 [DOI] 10.1007/s12127-016-0213-4.
2017
LipidMatch: an automated workflow for rule-based lipid identification using untargeted high-resolution tandem mass spectrometry data.
BMC bioinformatics. 18(1) [DOI] 10.1186/s12859-017-1744-3. [PMID] 28693421.
2017
LipidQC: Method Validation Tool for Visual Comparison to SRM 1950 Using NIST Interlaboratory Comparison Exercise Lipid Consensus Mean Estimate Values
Analytical Chemistry. 89(24):13069-13073 [DOI] 10.1021/acs.analchem.7b04042.
2017
Monitoring Dopamine ex Vivo during Electrical Stimulation Using Liquid-Microjunction Surface Sampling
Analytical Chemistry. 89(24):13658-13665 [DOI] 10.1021/acs.analchem.7b04463.
2017
Portable Faims: Applications and Future Perspectives
International Journal of Mass Spectrometry. 422:188-196 [DOI] 10.1016/j,ijms.2016.12.007.
2017
Portable FAIMS: Applications and Future Perspectives.
International journal of mass spectrometry. 422:188-196 [DOI] 10.1016/j.ijms.2016.12.007. [PMID] 29335669.
2017
Precast Gelatin-Based Molds for Tissue Embedding Compatible with Mass Spectrometry Imaging
Analytical Chemistry. 89(1):576-580 [DOI] 10.1021/acs.analchem.6b04185. [PMID] 27935272.
2016
Analysis of Ammonium Nitrate/Urea Nitrate with Crown Ethers and Sugars as Modifiers by Electrospray Ionization-Mass Spectrometry and Ion Mobility Spectrometry.
Analytical chemistry. 88(19):9435-9442 [PMID] 27573799.
2016
Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury.
Molecular & cellular proteomics : MCP. 15(7):2379-95 [DOI] 10.1074/mcp.M116.058115. [PMID] 27150525.
2016
Ion Mobility in Clinical Analysis: Current Progress and Future Perspectives.
Clinical chemistry. 62(1):124-33 [DOI] 10.1373/clinchem.2015.238840. [PMID] 26585928.
2016
Isotopic Ratio Outlier Analysis of the S. cerevisiae Metabolome Using Accurate Mass Gas Chromatography/Time-of-Flight Mass Spectrometry: A New Method for Discovery.
Analytical chemistry. 88(5):2747-54 [DOI] 10.1021/acs.analchem.5b04263. [PMID] 26820234.
2016
Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.
American journal of physiology. Endocrinology and metabolism. 310(7):E484-94 [DOI] 10.1152/ajpendo.00492.2015. [PMID] 26814015.
2016
Maternal exposure to di-2-ethylhexylphthalate and adverse delivery outcomes: A systematic review.
Reproductive toxicology (Elmsford, N.Y.). 65:76-86 [DOI] 10.1016/j.reprotox.2016.07.002. [PMID] 27412369.
2016
Skeletal muscle fiber analysis by atmospheric pressure scanning microprobe matrix-assisted laser desorption/ionization mass spectrometric imaging at high mass and high spatial resolution.
Proteomics. 16(11-12):1822-4 [DOI] 10.1002/pmic.201500536. [PMID] 27198224.
2015
Comparison of blood plasma sample preparation methods for combined LC–MS lipidomics and metabolomics
Journal of Chromatography B. 1002:260-266 [DOI] 10.1016/j.jchromb.2015.08.018. [PMID] 26343017.
2015
Ionization sources and mass analyzers in MS imaging.
Bioanalysis. 7(20):2629-37 [DOI] 10.4155/bio.15.187. [PMID] 26511148.
2015
Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells using Jurkat T lymphocyte Cells.
Journal of proteomics & bioinformatics. 8(6):126-132 [PMID] 26401069.
2015
Metabolomic Analysis of Oxidative and Glycolytic Skeletal Muscles by Matrix-Assisted Laser Desorption/IonizationMass Spectrometric Imaging (MALDI MSI).
Journal of the American Society for Mass Spectrometry. 26(6):915-23 [DOI] 10.1007/s13361-015-1133-y. [PMID] 25893271.
2015
Performance enhancement in the measurement of 5 endogenous steroids by LC-MS/MS combined with differential ion mobility spectrometry.
Clinica chimica acta; international journal of clinical chemistry. 438:330-6 [DOI] 10.1016/j.cca.2014.07.036. [PMID] 25110813.
2015
Solvent Vapor Effects in Planar High-Field Asymmetric Waveform Ion Mobility Spectrometry: Solvent Trends and Temperature Effects
International Journal of Mass Spectrometry. 378(SI):336-346 [DOI] 10.1016/j.ijms.2014.10.007.
2014
Standardized method for solubility and storage of capsaicin-based solutions for cough induction.
Cough (London, England). 10 [DOI] 10.1186/1745-9974-10-6. [PMID] 25342957.
2013
Characterization of phosphatidylcholine oxidation products by MALDI MS(n).
Analytical chemistry. 85(23):11410-9 [DOI] 10.1021/ac402400f. [PMID] 24180376.
2013
Identifying tissue-specific signal variation in MALDI mass spectrometric imaging by use of an internal standard.
Analytical chemistry. 85(2):1090-6 [DOI] 10.1021/ac3029618. [PMID] 23214468.
2013
Isotopic ratio outlier analysis global metabolomics of Caenorhabditis elegans.
Analytical chemistry. 85(24):11858-11865 [DOI] 10.1021/ac4025413. [PMID] 24274725.
2013
Jim Morrison, Friend and Colleague.
Journal of the American Society for Mass Spectrometry. 24(9):1319-23 [DOI] 10.1007/s13361-013-0692-z. [PMID] 23877476.
2013
Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard.
Analytical chemistry. 85(2):1081-9 [DOI] 10.1021/ac302960j. [PMID] 23214490.
2012
High-field asymmetric waveform ion mobility spectrometry with solvent vapor addition: a potential greener bioanalytical technique.
Bioanalysis. 4(11):1363-75 [DOI] 10.4155/bio.12.110. [PMID] 22720654.
2012
MALDI mass spectrometric imaging of cardiac tissue following myocardial infarction in a rat coronary artery ligation model.
Analytical chemistry. 84(2):1117-25 [DOI] 10.1021/ac202779h. [PMID] 22141424.
2011
Characterization of protonated phospholipids as fragile ions in quadrupole ion trap mass spectrometry.
International journal of mass spectrometry. 308(2-3):299-306 [PMID] 22247650.
2011
Comparison of rectangular and bisinusoidal waveforms in a miniature planar high-field asymmetric waveform ion mobility spectrometer.
Analytical chemistry. 83(24):9237-43 [DOI] 10.1021/ac200948b. [PMID] 22017325.
2011
Considerations for quantification of lipids in nerve tissue using matrix-assisted laser desorption/ionization mass spectrometric imaging.
Rapid communications in mass spectrometry : RCM. 25(20):3178-84 [DOI] 10.1002/rcm.5189. [PMID] 21953974.
2011
Direct matrix-assisted laser desorption/ionization mass spectrometric imaging of cellulose and hemicellulose in Populus tissue.
Analytical chemistry. 83(17):6722-30 [DOI] 10.1021/ac2013527. [PMID] 21766865.
2011
Lipid analysis of flat-mounted eye tissue by imaging mass spectrometry with identification of contaminants in preservation.
Analytical and bioanalytical chemistry. 401(1):103-13 [DOI] 10.1007/s00216-011-5044-x. [PMID] 21556752.
2011
Quantitative tandem mass spectrometric imaging of endogenous acetyl-L-carnitine from piglet brain tissue using an internal standard.
Analytical chemistry. 83(22):8575-81 [DOI] 10.1021/ac201949b. [PMID] 21942933.
2011
Solvent Vapor Effects On Planar High-Field Asymmetric Waveform Ion Mobility Spectrometry
International Journal of Mass Spectrometry. 300:173-181 [DOI] 10.1016/j.ijms.2010.04.002.
2010
Analysis of large peptides by MALDI using a linear quadrupole ion trap with mass range extension.
Analytical chemistry. 82(3):930-4 [DOI] 10.1021/ac9021488. [PMID] 20063857.
2010
Chemical characterization of Azadirachta indica grafted on Melia azedarach and analyses of azadirachtin by HPLC-MS-MS (SRM) and meliatoxins by MALDI-MS.
Phytochemical analysis : PCA. 21(4):363-73 [DOI] 10.1002/pca.1208. [PMID] 20333612.
2010
Design and Evaluation of a Novel Hemispherical Faims Cell
International Journal of Mass Spectrometry. 298:41-44 [DOI] 10.1016/j.ijms.2010.01.002.
2010
Quantitative MALDI-MS(n) analysis of cocaine in the autopsied brain of a human cocaine user employing a wide isolation window and internal standards.
Journal of the American Society for Mass Spectrometry. 21(4):564-71 [DOI] 10.1016/j.jasms.2009.12.014. [PMID] 20097576.
2010
Special Issue Ion Mobility Foreword
International Journal of Mass Spectrometry. 298 [DOI] 10.1016/j.ijms.2010.09.002.
2010
Tandem mass spectrometric methods for phospholipid analysis from brain tissue.
Methods in molecular biology (Clifton, N.J.). 656:209-30 [DOI] 10.1007/978-1-60761-746-4_12. [PMID] 20680593.
2009
Enhanced analysis of steroids by gas chromatography/mass spectrometry using microwave-accelerated derivatization.
Analytical chemistry. 81(16):6725-34 [DOI] 10.1021/ac900663c. [PMID] 19606839.
2009
Enhancement of chemical derivatization of steroids by gas chromatography/mass spectrometry (GC/MS).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(27):3237-42 [DOI] 10.1016/j.jchromb.2009.08.005. [PMID] 19692297.
2009
Evaluation of derivatization strategies for the comprehensive analysis of endocrine disrupting compounds using GC/MS.
Journal of chromatographic science. 47(1):44-51 [PMID] 19161656.
2009
Imaging of lipids in spinal cord using intermediate pressure matrix-assisted laser desorption-linear ion trap/Orbitrap MS.
Analytical chemistry. 81(20):8488-95 [DOI] 10.1021/ac901387u. [PMID] 19751051.
2009
Investigation of HPLC-MS using a monolithic column to separate a diverse suite of steroids.
Journal of chromatographic science. 47(1):52-6 [PMID] 19161657.
2008
Anyl 376-Separation and Characterization of Explosive Compounds Using High-Field Asymmetric Waveform Ion Mobility Spectrometry/Mass Spectrometry
. 236
2007
Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry.
Analytical chemistry. 79(17):6862-7 [PMID] 17658766.
2007
MALDI-linear ion trap microprobe MS/MS studies of the effects of dichloroacetate on lipid content of nerve tissue.
Analytical chemistry. 79(21):8170-5 [PMID] 17894472.
2007
Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.
Journal of pharmacological and toxicological methods. 55(3):279-88 [PMID] 17222568.
2006
Analysis of intact tissue by intermediate-pressure MALDI on a linear ion trap mass spectrometer.
Analytical chemistry. 78(7):2465-9 [PMID] 16579637.
2006
Human Kinetics of Orally and Intravenously Administered Low Dose 1,2-13C Dichloroacetate
Clinical Pharmacology & Therapeutics. 46(12):1449-1459
2006
Human kinetics of orally and intravenously administered low-dose 1,2-(13)C-dichloroacetate.
Journal of clinical pharmacology. 46(12):1449-59 [PMID] 17101744.
2005
Mass spectral fragmentation of the intravenous anesthetic propofol and structurally related phenols.
Journal of the American Society for Mass Spectrometry. 16(6):814-24 [PMID] 15907697.
2003
Internal energy deposition in chemical ionization/tandem mass spectrometry.
Journal of the American Society for Mass Spectrometry. 14(2):102-9 [PMID] 12586459.
2003
Simultaneous determination of trace levels of nine haloacetic acids in biological samples as their pentafluorobenzyl derivatives by gas chromatography/tandem mass spectrometry in electron capture negative ion chemical ionization mode.
Analytical chemistry. 75(16):4065-80 [PMID] 14632119.
2003
Synergistic attraction of Aedes aegypti (L.) to binary blends of L-lactic acid and acetone, dichloromethane, or dimethyl disulfide.
Journal of medical entomology. 40(5):653-6 [PMID] 14596278.
2002
Effects of fragile ions on mass resolution and on isolation for tandem mass spectrometry in the quadrupole ion trap mass spectrometer.
Analytical chemistry. 74(2):402-12 [PMID] 11811415.
2000
Analysis of human skin emanations by gas chromatography/mass spectrometry. 2. Identification of volatile compounds that are candidate attractants for the yellow fever mosquito (Aedes aegypti).
Analytical chemistry. 72(4):747-56 [PMID] 10701259.
2000
Interpretation of electrospray/ion trap mass spectra of bile acids and other surfactants.
Rapid communications in mass spectrometry : RCM. 14(15):1398-403 [PMID] 10920361.
1999
Analysis of human skin emanations by gas chromatography/mass spectrometry. 1. Thermal desorption of attractants for the yellow fever mosquito (Aedes aegypti) from handled glass beads.
Analytical chemistry. 71(1):1-7 [PMID] 9921122.
1996
Flavanone absorption after naringin, hesperidin, and citrus administration.
Clinical pharmacology and therapeutics. 60(1):34-40 [PMID] 8689809.
1995
Internal pulsed valve sample introduction on a quadrupole ion trap mass spectrometer.
Journal of the American Society for Mass Spectrometry. 6(10):976-80 [DOI] 10.1016/1044-0305(95)00528-L. [PMID] 24214042.
1994
Gas-phase ion-molecule reactions: a model for the determination of biologically reactive electrophilic contaminants in the environment.
Analytical chemistry. 66(11):1902-10 [PMID] 8030792.
1994
Infrared multiple photon dissociation in the quadrupole ion trap via a multipass optical arrangement.
Journal of the American Society for Mass Spectrometry. 5(10):886-93 [DOI] 10.1016/1044-0305(94)87013-6. [PMID] 24226234.
1994
Negative chemical ionization in quadrupole ion trap mass spectrometry: Effects of applied voltages and reaction times.
Journal of the American Society for Mass Spectrometry. 5(8):757-64 [DOI] 10.1016/1044-0305(94)80008-1. [PMID] 24222003.
1994
Short-column gas chromatography/tandem mass spectrometry for the detection of underivatized anabolic steroids in urine.
Biological mass spectrometry. 23(3):131-9 [PMID] 8148403.
1993
Nonlinear resonance effects during ion storage in a quadrupole ion trap.
Journal of the American Society for Mass Spectrometry. 4(12):917-29 [DOI] 10.1016/1044-0305(93)80017-S. [PMID] 24227599.
1992
Alternating RF/DC Isolations for Quantitation with Coeluting Internal Standards in Gas Chromatography/Ion Trap Mass Spectrometry.
Journal of the American Society for Mass Spectrometry. 3(1):85-8 [DOI] 10.1016/1044-0305(92)85022-C. [PMID] 24242841.
1992
Optimization of short-column gas chromatography/electron ionization mass spectrometry conditions for the determination of underivatized anabolic steroids.
Biological mass spectrometry. 21(9):420-30 [PMID] 1420379.
1992
Probing trapped ion energies via ion-molecule reaction kinetics: Quadrupole ion trap mass spectrometry.
Journal of the American Society for Mass Spectrometry. 3(7):716-26 [DOI] 10.1016/1044-0305(92)87084-C. [PMID] 24234638.
1990
Carbamazepine metabolism in humans: effect of concurrent anticonvulsant therapy.
Therapeutic drug monitoring. 12(3):235-41 [PMID] 2112276.
1990
Differences in the low-energy collision-activated dissociation of carboxylate anions from structurally similar prostaglandins: E2, F 2α, D 2, and DHKF 2α.
Journal of the American Society for Mass Spectrometry. 1(5):389-96 [DOI] 10.1016/1044-0305(90)85019-I. [PMID] 24248901.
1990
Estimation of mutagenic/carcinogenic potential of environmental contaminants by ion-molecule reactions and tandem mass spectrometry.
Journal of the American Society for Mass Spectrometry. 1(1):110-5 [DOI] 10.1016/1044-0305(90)80014-E. [PMID] 24248619.
1990
On-line mass spectrometric investigation of the peroxidase-catalysed oxidation of uric acid.
Journal of pharmaceutical and biomedical analysis. 8(2):205-15 [PMID] 2094419.
1990
Tandem mass spectrometry: quadrupole and hybrid instruments.
Methods in enzymology. 193:154-200 [PMID] 2074819.
1989
Characterization of solution-phase and gas-phase reactions in on-line electrochemistry-thermospray tandem mass spectrometry.
Journal of chromatography. 474(1):231-43 [PMID] 2768395.
1989
Concentrations of tryptoline and methtryptoline in rat brain.
Journal of neurochemistry. 52(3):847-52 [PMID] 2918311.
1989
On-line electrochemistry/thermospray/tandem mass spectrometry as a new approach to the study of redox reactions: the oxidation of uric acid.
Analytical chemistry. 61(15):1709-17 [PMID] 2774199.
1988
Degradation of N-methylcarbamate and carbamoyl oxime pesticides in chlorinated water.
Bulletin of environmental contamination and toxicology. 41(6):838-43 [PMID] 3233383.
1988
Electrochemistry/thermospray/tandem mass spectrometry in the study of biooxidation of purines.
Analytical chemistry. 60(7):720-2 [PMID] 3382022.
1988
Rapid identification of drug metabolites with tandem mass spectrometry.
Biomedical & environmental mass spectrometry. 15(4):193-204 [PMID] 3370359.
1986
Biotransformation and excretion: metabolite identification: other mass spectrometric methods.
Journal of clinical pharmacology. 26(6):435-42 [PMID] 3734133.
1986
Purification and quantification of arachidonate metabolites: critical evaluation of methods and interpretation of results.
Seminars in perinatology. 10(4):255-69 [PMID] 3105065.
1985
More on mass spectrometers and aerosol propellants.
Anesthesiology. 63(5):568-9 [PMID] 4051228.
1985
The use of tandem mass spectrometry for the identification and quantitation of tryptolines (tetrahydro-beta-carbolines) in tissue extracts.
Progress in clinical and biological research. 183:161-77 [PMID] 4048182.
1984
Comparison of mass spectrometric methods for trace level screening of hexachlorobenzene and trichlorophenol in human blood serum and urine.
Analytical chemistry. 56(12):2223-8 [PMID] 6507867.
1984
Pharmaceutical and clinical analysis by tandem mass spectrometry.
Talanta. 31(10 Pt 2):929-35 [PMID] 18963770.
1984
Quantitative measurement of octopamines and synephrines in urine using capillary column gas chromatography negative ion chemical ionization mass spectrometry.
Analytical chemistry. 56(9):1695-9 [PMID] 6435479.
1984
Rapid screening and confirmation for drugs and metabolites in racing animals by tandem mass spectrometry.
American journal of veterinary research. 45(11):2436-40 [PMID] 6524741.
1984
Tandem mass spectrometry for the trace determination of tryptolines in crude brain extracts.
Analytical chemistry. 56(9):1655-61 [PMID] 6486448.
1983
Determination of drugs in blood serum by mass spectrometry/mass spectrometry.
Analytical chemistry. 55(3):549-53 [PMID] 6846847.
1983
Oxygen fixation into hydroxyproline in etiolated maize seedlings : verification by tandem mass spectrometry.
Plant physiology. 73(3):860-1 [PMID] 16663315.
1979
Triple quadrupole mass spectrometry for direct mixture analysis and structure elucidation.
Analytical chemistry. 51(12):1251-64 [DOI] 10.1021/ac50048a002. [PMID] 21902234.
1977
Positive peak identification in liquid chromatography using absorbance ratioing with a variable-wavelength spectrophotometric detector.
Journal of chromatography. 134(1):73-82 [PMID] 870505.

Grants

Aug 2020 – Aug 2021
Eastman Fellowship Award for Taylor Domenick
Role: Other
Funding: EASTMAN FOUNDATION
Aug 2019 – Aug 2020
2019 Eastman Summer Grant or Fellowship in the area of Analytical Chemistry for Robin Kemperman
Role: Other
Funding: EASTMAN FOUNDATION
Aug 2018 – Jun 2023
Metabolomics Consortium Coordinating Center (M3C)
Role: Project Manager
Funding: NATL INST OF HLTH NIDDK
May 2018 – Oct 2020
Using Metabolomic Approaches to Investigate Treatments for Rare X-Chromosome Deletion Disorders
Role: Principal Investigator
Funding: XTRAORDINARY JOY FOUNDATION
Sep 2017 – Sep 2018
Lipidomics Software Development
Role: Principal Investigator
Funding: AGILENT TECHNOLOGIES
May 2017 – May 2018
Eastman Fellowship for Emily Gill Summer 2017
Role: Principal Investigator
Funding: EASTMAN FOUNDATION
Sep 2016 – Dec 2017
Ion MobilityMass Spectrometry for Improved Analysis of Exogenous Anabolic Steroids
Role: Principal Investigator
Funding: PARTNERSHIP FOR CLEAN COMPETITION
May 2016 – Apr 2019
Development of single-cell metabolomics to dissect cellular heterogeneity ofimmune cells
Role: Project Manager
Funding: NATL INST OF HLTH NIAID
Jul 2015 – Sep 2019
FlowProbe MS for Clinical Analysis
Role: Principal Investigator
Funding: PROSOLIA INC
Jul 2015 – Aug 2021
Cannabix Technologies Agreement
Role: Principal Investigator
Funding: CANNABIX TECHNOLOGIES INC
Jan 2015 – Oct 2019
FAIMS for Breath Testing
Role: Principal Investigator
Funding: BREATHTEC BIOMEDICAL INC
Jun 2014 – Jan 2022
Clinical Applications of Mass Spectrometry
Role: Principal Investigator
Funding: WELLSPRING CLINICAL LAB
Sep 2013 – Aug 2019
Southeast Resource Center for Integrated Metabolomics (SECIM)
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Sep 2013 – Dec 2018
Southeast Resource Center for Integrated Metabolomics (SECIM)
Role: Principal Investigator
Funding: FL CLINICAL PRACTICE ASSO
Sep 2013 – Aug 2018
DSR matching support – secim
Role: Principal Investigator
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Sep 2012 – Aug 2022
DSR Matching Support – Support for NSF Fellowship
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
May 2012 ACTIVE
Micro FAIMS/Triple Quad MS: Instrumental Studies and Ana
Role: Co-Investigator
Funding: AGILENT TECHNOLOGIES

Education

PhD Analytical Chemistry
1975-1979 · Michigan State University
BS Chemistry
1971-1974 · University of Arizona

Contact Details

Phones:
Business:
(352) 392-0557
Emails:
Business:
ryost@ufl.edu
Addresses:
Business Mailing:
PO Box 117200
GAINESVILLE FL 32611
Business Street:
CLB 210A
GAINESVILLE FL 326110001