2020 – 2022 Publications

See below for a list of publications that highlight research that was conducted with the support of SECIM.

2022

Du X, Aristizabal-Henao JJ, Garrett TJ, Brochhausen M, Hogan WR, Lemas DJ. A Checklist for Reproducible Computational Analysis in Clinical Metabolomics Research. Metabolites. 2022 Jan 17;12(1):87. doi: 10.3390/metabo12010087. PMID: 35050209

Hadrava Vanova K, Pang Y, Krobova L, Kraus M, Nahacka Z, Boukalova S, Pack SD, Zobalova R, Zhu J, Huynh TT, Jochmanova I, Uher O, Hubackova S, Dvorakova S, Garrett TJ, Ghayee HK, Wu X, Schuster B, Knapp PE, Frysak Z, Hartmann I, Nilubol N, Cerny J, Taieb D, Rohlena J, Neuzil J, Yang C, Pacak K. Germline SUCLG2 Variants in Patients With Pheochromocytoma and Paraganglioma.  J Natl Cancer Inst. 2022 Jan 11;114(1):130-138. doi: 10.1093/jnci/djab158. PMID: 34415331

Koelmel JP, Tan WY, Li Y, Bowden JA, Ahmadireskety A, Patt AC, Orlicky DJ, Mathé E, Kroeger NM, Thompson DC, Cochran JA, Golla JP, Kandyliari A, Chen Y, Charkoftaki G, Guingab-Cagmat JD, Tsugawa H, Arora A, Veselkov K, Kato S, Otoki Y, Nakagawa K, Yost RA, Garrett TJ, Vasiliou V. Lipidomics and Redox Lipidomics Indicate Early Stage Alcohol-Induced Liver Damage. Hepatol Commun. 2022 Mar;6(3):513-525. doi: 10.1002/hep4.1825. Epub 2021 Nov 23. PMID: 34811964

Pinto FG, Mahmud I, Rubio VY, Máquina ADV, Furtado Durans AF, Neto WB, Garrett TJ. Data-Driven Soft Independent Modeling of Class Analogy in Paper Spray Ionization Mass Spectrometry-Based Metabolomics for Rapid Detection of Prostate Cancer. Anal Chem. 2022 Feb 1;94(4):1925-1931. doi: 10.1021/acs.analchem.1c04004. Epub 2022 Jan 21. PMID: 35060703

Suganuma T, Swanson SK, Gogol M, Garrett TJ, Florens L, Workman JL. MOCS2 links nucleotide metabolism to nucleoli function.  J Mol Cell Biol. 2022 Jan 21;13(11):838-840. doi: 10.1093/jmcb/mjab069. PMID: 34698840

Santoro C, O’Toole A, Finsel P, Alvi A, Musselman LP. Reducing ether lipids improves Drosophila overnutrition-associated pathophysiology phenotypes via a switch from lipid storage to beta-oxidation. Sci Rep. 2022 Jul 29;12(1):13021. doi: 10.1038/s41598-022-16870-4. PMID: 35906462; PMCID: PMC9338069.

Tikunov AP, Tipton JD, Garrett TJ, Shinde SV, Kim HJ, Gerber DA, Herring LE, Graves LM, Macdonald JM. Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses. Methods Mol Biol. 2022 ;2394:267-298. doi: 10.1007/978-1-0716-1811-0_17. PMID: 35094334

2021

Chamberlain CA, Hatch M, Garrett TJ. Extracellular Vesicle Analysis by Paper Spray Ionization Mass Spectrometry. Metabolites. 2021 May 11;11(5):308. doi: 10.3390/metabo11050308.PMID: 34065030

Fu Z, Dean JW, Xiong L, Dougherty MW, Oliff KN, Chen ZE, Jobin C, Garrett TJ, Zhou L.  Mitochondrial transcription factor A in RORγt + lymphocytes regulate small intestine homeostasis and metabolismNat Commun. 2021 Jul 22;12(1):4462. doi: 10.1038/s41467-021-24755-9. PMID: 34294718

Henry JA, Khattri RB, Guingab-Cagmat J, Merritt ME, Garrett TJ, Patterson JT, Lohr KE. Intraspecific variation in polar and nonpolar metabolite profiles of a threatened Caribbean coral. Metabolomics. 2021 Jun 18;17(7):60. doi: 10.1007/s11306-021-01808-0.PMID: 34143280

Koelmel JP, Aristizabal-Henao JJ, Ni Z, Fedorova M, Kato S, Otoki Y, Nakagawa K, Lin EZ, Godri Pollitt KJ, Vasiliou V, Guingab JD, Garrett TJ, Williams TL, Bowden JA, Penumetcha M. A Novel Technique for Redox Lipidomics Using Mass Spectrometry: Application on Vegetable Oils Used to Fry Potatoes. J Am Soc Mass Spectrom. 2021 Jul 7;32(7):1798-1809. doi: 10.1021/jasms.1c00150. PMID: 34096708

Koomen DC, Meads MB, Magaletti DM, Guingab-Cagmat JD, Oliveira PS, Fang B, Liu M, Welsh EA, Meke LE, Jiang Z, Hampton OA, Tungesvik A, De Avila G, Alugubelli RR, Nishihori T, Silva AS, Eschrich SA, Garrett TJ, Koomen JM, Shain KH. Metabolic Changes Are Associated with Melphalan Resistance in Multiple Myeloma. J Proteome Res. 2021 Jun 4;20(6):3134-3149. doi: 10.1021/acs.jproteome.1c00022. Epub 2021 May 20. PMID: 34014671.

Lauro F, Giancotti LA, Kolar G, Harada CM, Harmon TA, Garrett TJ, Salvemini D. Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.  Cell Mol Neurobiol. 2021 Nov 13. doi: 10.1007/s10571-021-01162-8. PMID: 34773542

Mahmud I, Pinto FG, Rubio VY, Lee B, Pavlovich CP, Perera RJ, Garrett TJ. Rapid Diagnosis of Prostate Cancer Disease Progression Using Paper Spray Ionization Mass Spectrometry. Anal Chem. 2021 Jun 8;93(22):7774-7780. doi: 10.1021/acs.analchem.1c00943. Epub 2021 May 27. PMID: 34043339

Menzies V, Starkweather A, Yao Y, Kelly DL, Garrett TJ, Yang G, Booker S, Swift-Scanlan T, Mahmud I, Lyon DE. Exploring Associations Between Metabolites and Symptoms of Fatigue, Depression and Pain in Women With Fibromyalgia. Biol Res Nurs. 2021 Jan;23(1):119-126. doi: 10.1177/1099800420941109. Epub 2020 Jul 17. PMID: 32677448; PMCID: PMC7874366.

O’Kell AL, Wasserfall C, Guingab-Cagmat J, Webb-Roberston BM, Atkinson MA, Garrett TJ. Targeted metabolomic analysis identifies increased serum levels of GABA and branched chain amino acids in canine diabetes. Metabolomics. 2021 Nov 14;17(11):100. doi: 10.1007/s11306-021-01850-y. PMID: 34775536

Russell JT, Ruoss JL, de la Cruz D, Li N, Bazacliu C, Patton L, McKinley KL, Garrett TJ, Polin RA, Triplett EW, Neu J.  Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants.  Scientific Reports, 2021. 11, 1, 1-16.

Stockard B, Bhise N, Shin M, Guingab-Cagmat J, Garrett TJ, Pounds S, Lamba JK. Cellular Metabolomics Profiles Associated With Drug Chemosensitivity in AML. Front Oncol. 2021 Jun 10;11:678008. doi: 10.3389/fonc.2021.678008. eCollection 2021.PMID: 34178663 

Tantawy M, Chekka LM, Huan Y, Garrett TJ, Singh S, Shah C, Cornell RF, Baz RC, Fradley MG, Waheed N, Deremer DL, Yuan L, Langaee T, March K, Pepine C, Moreb JS, Gong Y.  Frontiers in Cardiovascular Medicine, 2021, 8, 206. 

Tan SK, Mahmud I, Fontanesi F, Puchowicz M, Neumann CKA, Griswold AJ, Patel R, Dispagna M, Ahmed HH, Gonzalgo ML, Brown JM, Garrett TJ, Welford SM.  Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance.  2021, Cancer Discovery, just accepted. 

Teixeira LD, Torrez Lamberti MF, DeBose-Scarlett E, Bahadiroglu E, Garrett TJ, Gardner CL, Meyer JL, Lorca GL, Gonzalez CF. Lactobacillus johnsonii N6.2 and Blueberry Phytophenols Affect Lipidome and Gut Microbiota Composition of Rats Under High-Fat Diet. Front Nutr. 2021 Oct 14;8:757256. doi: 10.3389/fnut.2021.757256. PMID: 34722616

Tuthill Ii BF, Quaglia CJ, O’Hara E, Musselman LP. Loss of Stearoyl-CoA desaturase 1 leads to cardiac dysfunction and lipotoxicity. J Exp Biol. 2021 Sep 15;224(18):jeb240432. doi: 10.1242/jeb.240432. Epub 2021 Oct 1. PMID: 34423827; PMCID: PMC8502255.

Yazd HS, Bazargani SF, Vanbeek CA, King-Morris K, Heldermon C, Segal MS, Clapp WL, Garrett TJ. LC-MS lipidomics of renal biopsies for the diagnosis of Fabry disease. J Mass Spectrom Adv Clin Lab. 2021 Nov 26;22:71-78. doi: 10.1016/j.jmsacl.2021.11.004. eCollection 2021 Nov. PMID: 34918004

Yazd HS, Rubio VY, Chamberlain CA, Yost RA, Garrett TJ. Metabolomic and lipidomic characterization of an X-chromosome deletion disorder in neural progenitor cells by UHPLC-HRMS. J Mass Spectrom Adv Clin Lab. 2021 May 29;20:11-24. doi: 10.1016/j.jmsacl.2021.05.002. eCollection 2021 Apr. PMID: 34820667

Wakefield ZR, Tanaka M, Pampo C, Lepler S, Rice L, Guingab-Cagmat J, Garrett TJ, Siemann DW. Normal tissue and tumor microenvironment adaptations to aerobic exercise enhance doxorubicin anti-tumor efficacy and ameliorate its cardiotoxicity in retired breeder mice. Oncotarget. 2021 Aug 31;12(18):1737-1748. doi: 10.18632/oncotarget.28057. eCollection 2021 Aug 31.PMID: 34504647

2020

Patton L, Li N, Garrett TJ, Ruoss JL, Russell JT, de la Cruz D, Bazacliu C, Polin RA, Triplett EW, Neu J. Antibiotics Effects on the Fecal Metabolome in Preterm Infants. Metabolites. 2020 Aug 13;10(8):331. doi: 10.3390/metabo10080331. PMID: 32823682; PMCID: PMC7464203.

Mahmud I, Garrett TJ. Mass Spectrometry Techniques in Emerging Pathogens Studies: COVID-19 Perspectives. J Am Soc Mass Spectrom. 2020 Oct 7;31(10):2013-2024. doi: 10.1021/jasms.0c00238. Epub 2020 Sep 16. PMID: 32880453; PMCID: PMC7496948.

Taylor NJ, Gaynanova I, Eschrich SA, Welsh EA, Garrett TJ, Beecher C, Sharma R, Koomen JM, Smalley KSM, Messina JL, Kanetsky PA. Metabolomics of primary cutaneous melanoma and matched adjacent extratumoral microenvironment. PLoS One. 2020 Oct 27;15(10):e0240849. doi: 10.1371/journal.pone.0240849. PMID: 33108391; PMCID: PMC7591037.

Klupczynska A, Plewa S, Dereziński P, Garrett TJ, Rubio VY, Kokot ZJ, Matysiak J. Identification and quantification of honeybee venom constituents by multiplatform metabolomics. Sci Rep. 2020 Dec 10;10(1):21645. doi: 10.1038/s41598-020-78740-1. PMID: 33303913; PMCID: PMC7729905.